PhD Thesis: Neural mechanisms of proactive and reactive inhibition

My PhD thesis is about the neural mechanisms of proactive inhibition (goal-directed action restraint) and reactive inhibition (stimulus-drive action cancelation) and how schizophrenia impacts these forms of control. The main findings of this research can be summarized as follows:

  1. The right inferior frontal cortex appears involved in reactive inhibition, whereas the striatum and supplementary motor complex are engaged both in proactive and reactive inhibition. These findings challenge the common view that the entire neural network activated during stopping is recruited in preparation for stopping.
  2. During reactive inhibition, the right inferior frontal cortex exerts control over the primary motor cortex via a cortico-basal ganglua pathway that includes supplementary motor complex and the striatum.
  3. Schizophrenia is associated with reduced proactive inhibition and this impairment is associated with frontostriatal dysfunction and working memory capacity limitations.

All chapters in this thesis have now been published as research articles in international peer-reviewed journals:

  • Zandbelt, B. B., & Vink, M. (2010). On the role of the striatum in response inhibition. PloS ONE, 5(11), e13848.
  • Zandbelt, B. B., Bloemendaal, M., Hoogendam, J. M., Kahn, R. S., & Vink, M. (2013). Transcranial magnetic stimulation and functional MRI reveal cortical and subcortical interactions during stop-signal response inhibition. Journal of Cognitive Neuroscience, 25(2), 157-174.
  • Zandbelt, B. B., Bloemendaal, M., Neggers, S. F., Kahn, R. S., & Vink, M. (2013). Expectations and violations: Delineating the neural network of proactive inhibitory control. Human Brain Mapping, 34(9), 2015-2024.
  • Zandbelt, B. B., van Buuren, M., Kahn, R. S., & Vink, M. (2011). Reduced proactive inhibition in schizophrenia is related to corticostriatal dysfunction and poor working memory. Biological Psychiatry, 70(12), 1151-1158.